Publications
Pre-Independent Research
19. Gering, H. E.; Manley, O. M.; Holwerda, A. J.; Grant, J. L.; Ratigan, S. C.; Makris, T. M. Regulation of ferryl reactivity by the cytochrome P450 decarboxylase OleT. Journal of Inorganic Biochemistry 2025, 270, 112912. DOI: https://doi.org/10.1016/j.jinorgbio.2025.112912
18. Manley, O. M.; Rosenzweig, A. C. Copper-chelating natural products. Journal of Biological Inorganic Chemistry 2025, 30, 111–124. DOI: https://doi.org/10.1007/s00775-025-02099-9
17. Manley, O. M.; Shriver, T. J.; Xu, T.; Melendrez, I. A.; Palacios, P.; Robson, S. A.; Guo, Y.; Kelleher, N. L.; Ziarek, J. J.; Rosenzweig, A. C. A multi-iron enzyme installs copper-binding oxazolone/thioamide pairs on a nontypeable Haemophilus influenzae virulence factor. Proceedings of the National Academy of Sciences 2024, 121 (28), e2408092121. DOI: https://doi.org/10.1073/pnas.2408092121
16. Amaya, J. A.; Manley, O. M. (co-first); Bian, J. C.; Rutland, C. D.; Leschinsky, N.; Ratigan, S. C.; Makris, T. M. Enhancing ferryl accumulation in H2O2-dependent cytochrome P450s. Journal of Inorganic Biochemistry 2024, 252, 112458. DOI: https://doi.org/10.1016/j.jinorgbio.2023.112458
15. Phan, H. N.; Manley, O. M.; Skirboll, S. S.; Cha, L.; Hilovsky, D.; Chang, W.-c.; Thompson, P. M.; Liu, X.; Makris, T. M. Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD. Biochemistry 2023, 62 (22), 3276–3282. DOI: https://doi.org/10.1021/acs.biochem.3c00406
14. Jahirul Islam, M.; Park, K. C.; Manley, O. M.; Smith, M. D.; Makris, T. M.; Peryshkov, D. V. Room-Temperature Aerobic C–CN Bond Activation in Nickel(II) Cyanomethyl Dicarboranyl Complex. Organometallics 2023, 42 (15), 1997-2004. DOI: https://doi.org/10.1021/acs.organomet.3c00216
13. Manley, O. M.; Phan, H. N.; Stewart, A. K.; Mosley, D. A.; Xue, S.; Cha, L.; Bai, H.; Lightfoot, V. C.; Rucker, P. A.; Collins, L.; Islam Williams, T.; Chang, W.-c.; Guo, Y.; Makris, T. M. Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis. Proceedings of the National Academy of Sciences 2022, 119 (39), e2210908119. DOI: https://doi.org/10.1073/pnas.2210908119
12. Dutra, M.; Amaya, J. A.; McElhenney, S.; Manley, O. M.; Makris, T. M.; Rassolov, V.; Garashchuk, S. Experimental and Theoretical Examination of the Kinetic Isotope Effect in Cytochrome P450 Decarboxylase OleT. Journal of Physical Chemistry B 2022, 126 (19), 3493–3504. DOI: https://doi.org/10.1021/acs.jpcb.1c10280
11. Dutra, M.; McElhenney, S.; Manley, O. M.; Makris, T. M.; Rassolov, V.; Garashchuk, S. Modeling the Ligand Effect on the Structure of CYP 450 Within the Density Functional Theory. Journal of Physical Chemistry A 2022, 126 (18), 2818–2824. DOI: https://doi.org/10.1021/acs.jpca.2c01783
10. Martin, C. R. Park, K. C.; Leith, G. A.; Yu, J.; Mathur, A.; Wilson, G. R.; Gange, G. B.; Barth, E. L.; Ly, R. T.; Manley, O. M.; Forrester, K. L.; Karakalos, S. K.; Smith, M. D.; Makris, T. M.; Vannucci, A. K.; Peryshkov, D. V.; B. Shustova, N. B. Stimuli-Modulated Metal Oxidation States in Photochromic MOFs. Journal of the American Chemical Society 2022, 144 (10), 4457–4468. DOI: https://doi.org/10.1021/jacs.1c11984
9. Manley, O. M.; Tang, H.; Xue, S.; Guo, Y.; Chang, W.-c.; Makris, T. M. BesC Initiates C–C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate. Journal of the American Chemical Society 2021, 143 (50), 21416–21424. DOI: https://doi.org/10.1021/jacs.1c11109
— Featured JACS Spotlight article: https://doi.org/10.1021/jacs.1c13329
8. Manley, O. M.; Makris, T. M. 8.12. Cytochrome P450 Enzyme Mechanisms. In Comprehensive Coordination Chemistry III. 3rd Edition. Constable, E.; Parkin, G.; Que, L.; Eds. Elsevier. 2021, 254–268. DOI: https://doi.org/10.1016/B978-0-08-102688-5.00054-4
7. Metavarayuth, K.; Ejegbavwo, O.; McCarver, G.; Myrick, M.; Makris, T.; Vogiatzis, K.; Senanayake, S.; Manley, O. M.; Ebrahim, A.; Frenkel, A.; Hwang, S.; Rajeshkumar, T.; Jimenez, J.; Chen, K.; Shustova, N.; Chen, D. Direct Identification of Mixed-Metal Centers in Metal-Organic Frameworks: Cu3(BTC)2 Transmetallated with Rh2+ Ions. Journal of Physical Chemistry Letters 2020, 11(19), 8138–8144. DOI: https://doi.org/10.1021/acs.jpclett.0c02539
6. Zhang, L.; Manley, O. M.; Ma, D.; Yin, Y.; Makris, T. M.; Wang, Q. Enhanced P450 fatty acid decarboxylase catalysis by glucose oxidase coupling and co-assembly for biofuel generation. Bioresource Technology 2020, 311, 123538. DOI: https://doi.org/10.1016/j.biortech.2020.123538
5. Manley, O. M.; Myers, P. D.; Toney, D. J.; Bolling, K. F.; Rhodes, L. C.; Gasparik, J. L.; Grossoehme, N. E. Evaluation of the regulatory model for Ni2+ sensing by Nur from Streptomyces coelicolor. Journal of Inorganic Biochemistry 2020, 203, 110859. DOI: https://doi.org/10.1016/j.jinorgbio.2019.110859
4. Manley, O. M.; Fan, R.; Guo, Y.; Makris, T. M. Oxidative Decarboxylase UndA Utilizes a Dinuclear Iron Cofactor. Journal of the American Chemical Society 2019, 141 (22), 8684–8688. DOI: https://doi.org/10.1021/jacs.9b02545
3. Wise, C. E.; Grant, J. L.; Amaya, J. A.; Ratigan, S. C.; Hsieh, C. H.; Manley, O. M.; Makris, T. M. Divergent mechanisms of iron-containing enzymes for hydrocarbon biosynthesis. Journal of Biological Inorganic Chemistry 2017, 22 (2–3), 221–235. DOI: https://doi.org/10.1007/s00775-016-1425-0
2. Johnson, R. A.; Manley, O. M.; Spuches, A. M.; Grossoehme, N. E. Dissecting ITC data of metal ions binding to ligands and proteins. Biochimica et Biophysica Acta 2016, 1860 (5), 892–901. DOI: https://doi.org/10.1016/j.bbagen.2015.08.018
1. Manley, O. M. A mathematical model of cancer networks with radiation therapy. Journal of Young Investigators 2014, 27 (6), 17–26.